Pd17-02 Comparison of 68-Ga-Psma Pet/Ct and Multiparametric Mri in Detecting Lymph Node Metastases in Patients With Intermediate or High Risk Prostate Cancer

You have accessJournal of UrologyProstate Cancer: Staging I (PD17)1 May 2024PD17-02 COMPARISON OF 68-GA-PSMA PET/CT AND MULTIPARAMETRIC MRI IN DETECTING LYMPH NODE METASTASES IN PATIENTS WITH INTERMEDIATE OR HIGH RISK PROSTATE CANCER Sanjay Kumar, Prashant Singh, Rakesh Kumar, Chhama Singh, Akshima Sharma, Amlesh Seth, Sanjay Sharma, Seema Kaushal, and Chandan J. Das Sanjay KumarSanjay Kumar , Prashant SinghPrashant Singh , Rakesh KumarRakesh Kumar , Chhama SinghChhama Singh , Akshima SharmaAkshima Sharma , Amlesh SethAmlesh Seth , Sanjay SharmaSanjay Sharma , Seema KaushalSeema Kaushal , and Chandan J. DasChandan J. Das View All Author Informationhttps://doi.org/10.1097/01.JU.0001010044.70939.31.02AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: This study compared the effectiveness of 68Ga-PSMA PET/CT and multiparametric MRI (mpMRI) in lymph node staging of intermediate and high-risk prostate cancer (CaP). METHODS: Patients with biopsy-proven intermediate or high-risk CaP who were potential candidates for radical prostatectomy (RP) were prospectively enrolled in the study. Each patient underwent 68Ga-PSMA-PET/CT and mpMRI for staging workup prior to RP. After RP, taking HPE as the gold standard, performance of 68Ga-PSMA PET/CT and mpMRI were compared in determining lymph node involvement. RESULTS: 92 CaP patients (57 intermediate risk and 35 high risk) were included in the study (Table 1). Out of 92 patients, the post-RP HPE confirmed regional lymph node involvement in 8 patients, amongst which ⁶⁸Ga-PSMA-PET/CT was positive for 7 and mpMRI was positive for 2. The results show that 68Ga-PSMA PET/CT has a higher sensitivity, specificity, Negative predictive value (NPV), Positive predictive value (PPV), and accuracy (87.50%, 97.60%, 77.80%, 98.80%, 96.70%) than mpMRI (40%, 93.10%, 96.40%, 25%, 90.21%) for the detection of lymph node metastasis (Tables 2, 3, Figure 1). This means that 68Ga-PSMA PET/CT is more likely to correctly identify patients with lymph node metastasis and less likely to produce false positives or false negatives. CONCLUSIONS: This study suggests that 68Ga-PSMA PET/CT is a superior imaging modality to mpMRI for the detection of lymph node metastasis in intermediate and high risk prostate cancer patients. Download PPT Source of Funding: Indian Council of Medical Research (ICMR) © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e370 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Sanjay Kumar More articles by this author Prashant Singh More articles by this author Rakesh Kumar More articles by this author Chhama Singh More articles by this author Akshima Sharma More articles by this author Amlesh Seth More articles by this author Sanjay Sharma More articles by this author Seema Kaushal More articles by this author Chandan J. Das More articles by this author Expand All Advertisement PDF downloadLoading ...