Mp09-18 Causal Associations of Immune Cells With Benign Prostatic Hyperplasia: Insights From a Mendelian Randomization Study

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Epidemiology, Evaluation & Medical Non-surgical Therapy (MP09)1 May 2024MP09-18 CAUSAL ASSOCIATIONS OF IMMUNE CELLS WITH BENIGN PROSTATIC HYPERPLASIA: INSIGHTS FROM A MENDELIAN RANDOMIZATION STUDY Tiewen Li and Yuan Ruan Tiewen LiTiewen Li and Yuan RuanYuan Ruan View All Author Informationhttps://doi.org/10.1097/01.JU.0001008920.55771.18.18AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Benign Prostatic Hyperplasia (BPH) stands as one of the most prevalent conditions among elderly males, significantly impacting the patients' overall quality of life. Prior observational research has suggested an elevated presence of immune cell infiltration within the expanding prostate tissues, generating a spectrum of pro-inflammatory cytokines and chemokines. Our study has implemented a comprehensive two-sample MR method to examine the causal relationship between immune cel traits and BPH. METHODS: Our study employed a comprehensive two-sample MR analysis to determine the causal relationships between immune cell characteristics and BPH. Utilizing publicly available genetic data, we scrutinized 731 immune cell characteristics and their association with BPH risk. Thorough sensitivity analyses were utilized to validate the robustness, heterogeneity, and potential horizontal pleiotropy of the results. RESULTS: 38 immune cell characteristics were found to have a causal effect on BPH. Subsequently, three of these immune cell characteristics were verified in reverse MR analyses, which included CD19 on IgD+ CD38dim (β = -0.022, 95% CI=0.958 to 0.998, p=0.030), CD19 on IgD+ (β = -0.022, 95% CI=0.959 to 0.998, p=0.032), and CD19 on naive-mature B cell (β = -0.029, 95% CI=0.949 to 0.993, p=0.011). Furthermore, BPH exhibited a significant association with these three immune cell phenotypes: CD19 on IgD+ CD38dim (β = -0.152, 95% CI=0.746 to 0.989, p=0.034), CD19 on IgD+ (β = -0.167, 95% CI=0.737 to 0.973, p=0.019), and CD19 on naive-mature B cell (β = -0.166, 95% CI=0.737 to 0.972, p=0.018). CONCLUSIONS: Our study, employing genetic methodologies, established the close connection between immune cells and BPH, offering guidance for future clinical investigations. Source of Funding: National Natural Science Foundation of China © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e134 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Tiewen Li More articles by this author Yuan Ruan More articles by this author Expand All Advertisement PDF downloadLoading ...