Mp69-20 Uti Symptoms in "Healthy" Adults

You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Kidney & Bladder I (MP69)1 May 2024MP69-20 UTI SYMPTOMS IN "HEALTHY" ADULTS Faizanahmed I. Munshi, Sreeya Komaravolu, Sarah Anne Moore, Emery Haley, Xiaofei Chen, Richard A. Festa, Natalie Luke, Jim Havrilla, Mohit Mathur, David Baunoch, and Dicken S. C. Ko Faizanahmed I. MunshiFaizanahmed I. Munshi , Sreeya KomaravoluSreeya Komaravolu , Sarah Anne MooreSarah Anne Moore , Emery HaleyEmery Haley , Xiaofei ChenXiaofei Chen , Richard A. FestaRichard A. Festa , Natalie LukeNatalie Luke , Jim HavrillaJim Havrilla , Mohit MathurMohit Mathur , David BaunochDavid Baunoch , and Dicken S. C. KoDicken S. C. Ko View All Author Informationhttps://doi.org/10.1097/01.JU.0001008892.86171.de.20AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: We aimed to measure the self-reported frequency of urinary tract infection (UTI) symptoms in "healthy" adult volunteers. METHODS: Adult (≥18) self-reported "healthy" volunteers gave written informed consent (Western IRB 20230847) and provided a midstream urine specimen. Subjects who were pregnant, or taking antibiotics or steroids were excluded. A total of 619 subjects from 2 states were recruited from the community (at stores, sporting events, social gatherings, etc.) between 2/28/2023 and 3/22/2023. All specimens underwent standard urine culture (SUC) and multiplex polymerase chain reaction (M-PCR) testing (Guidance® UTI, Pathnostics in Irvine, CA) for microbial detection, as previously described. Symptom status was determined by the US Food and Drug Administration (FDA) symptom scores on the validated American English Acute Cystitis Symptom Score (ACSS) Questionnaire, asking patients to evaluate four typical UTI symptoms: urinary frequency, urinary urgency, dysuria, and suprapubic pain, as well as visible blood in the urine, according to each one's severity (scoring 0–3): no (0), mild (1), moderate (2), severe (3). Asymptomatic cases were defined as having four FDA symptom scores adding up to ≤4, none of the four symptom scores being >1, and the absence of visible blood in the urine. RESULTS: Surprisingly, 21% (127) of volunteers were determined to be symptomatic for UTI, with males experiencing significantly more dysuria, females experiencing more suprapubic pain, and both experiencing more urinary frequency and urgency than the asymptomatic group. Of those, 39 (31%) were negative by both SUC and Guidance, indicating that 88 (69%) were positive by SUC and/or Guidance. Furthermore, 24% of symptomatic adults (age 50-69) and 24% of symptomatic men reported that their symptoms were severe enough to interfere with their work or social activities. CONCLUSIONS: A significant percentage of self-identified "healthy" volunteers also report significant UTI symptoms. These individuals, who are predominantly male, and/or older adults (≥50 years of age), could potentially benefit from medical evaluation and treatment especially when considering 69% of symptomatic individuals had positive SUC and/or Guidance results. Download PPTDownload PPT Source of Funding: Pathnostics, Irvine, CA © 2024 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e1126 Advertisement Copyright & Permissions© 2024 by American Urological Association Education and Research, Inc.Metrics Author Information Faizanahmed I. Munshi More articles by this author Sreeya Komaravolu More articles by this author Sarah Anne Moore More articles by this author Emery Haley More articles by this author Xiaofei Chen More articles by this author Richard A. Festa More articles by this author Natalie Luke More articles by this author Jim Havrilla More articles by this author Mohit Mathur More articles by this author David Baunoch More articles by this author Dicken S. C. Ko More articles by this author Expand All Advertisement PDF downloadLoading ...