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Aim: To estimate the cost–effectiveness of zolbetuximab plus capecitabine/oxaliplatin (CAPOX) in CLDN18. 2-positive, HER2-negative, mG/GEJ adenocarcinoma from the perspective of Chinese payers. Materials & methods: A partitioned survival model was developed to assess the costs, quality-adjusted life years (QALYs) and incremental cost–effectiveness ratios (ICER) of zolbetuximab plus CAPOX versus placebo plus CAPOX. Sensitivity analyses were performed to test the robustness of model. Results: Zolbetuximab plus CAPOX gained an additional cost of 91, 551 and an extra health benefit of 0. 24 QALY over placebo plus CAPOX, producing an ICER of 388, 186/QALY, which exceeded the willingness-to-pay threshold of 38, 223/QALY. Sensitivity analysis shows that the model was generally robust. Conclusion: Zolbetuximab plus CAPOX would not be a cost-effective first-line treatment regimen in CLDN18. 2-positive, HER2-negative, mG/GEJ adenocarcinoma in China.
Lai et al. (Fri,) studied this question.