FOXO1 is a master regulator of memory programming in CAR T cells

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1. 1Discovery of Novel Forkhead Box O1 Inhibitors for Treating Type 2 Diabetes: Improvement of Fasting Glycemia in Diabetic db/db Mice2010 · 278 citations
2. 2Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell–Intrinsic Dysfunction2023 · 34 citations
3. 3IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors2020 · 107 citations
4. 4Integrative Bulk and Single-Cell Profiling of Premanufacture T-cell Populations Reveals Factors Mediating Long-Term Persistence of CAR T-cell Therapy2021 · 206 citations
5. 5Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells2017 · 101 citations