Key points are not available for this paper at this time.
Introduction. Coronary heart disease (CHD) is the most common form of heart disease, which is one of the leading causes of death in the world.A combination of several factors has a special effect on the course of coronary heart disease, which significantly worsens the unfavorable prognosis. Purpose: to determine the correlations of the studied indicators in patients with coronary artery disease against the background of metabolic syndrome. Research methods. 60 patients had verified coronary heart disease without metabolic syndrome - group 1, the other 60 patients had verified coronary heart disease (CHD) complicated by metabolic syndrome (MS) - group 2. In order to identify correlations, the linear correlation coefficient |r|between all studied indicators. Results and discussion. In both groups of patients, the main interactions were found between glucose content and other indicators, as well as numerous correlations of lipid metabolism indicators with other studied indicators.In the group of patients with coronary artery disease, strong positive correlations were found between the creatinine clearance index and hemoglobin concentration; hematocrit; content of erythrocytes; a strong negative relationship with the age of patients. In the group of patients with MS, strong positive correlations were found between creatinine clearance and NT-proBNP, ST 2, and pro-inflammatory cytokines. Conclusion. When analyzing the obtained results, numerous correlations of lipid metabolism indicators with other studied indicators were found.In coronary heart disease against the background of metabolic syndrome, a direct pathogenetic connection of hyperglycemia with pro-inflammatory interleukin, which activates the cellular link of non-specific immunity (phagocytosis), is revealed. The depressing effect of hyperglycemia on other links of immune defense and indicators of lipid metabolism is also revealed.ST 2 positively correlates with NT-proBNP indicators in patients with coronary artery disease on the background of MS, which indicates the presence of ischemic and metabolic disorders in these patients.
Shchurko et al. (Tue,) studied this question.