On‐Demand Cueing for Freezing of Gait in Parkinson's Disease: A Randomized Controlled Trial

Abstract Background Cueing can alleviate freezing of gait (FOG) in people with Parkinson's disease (PD), but using the same cues continuously in daily life may compromise effectiveness. Therefore, we developed the DeFOG‐system to deliver personalized auditory cues on detection of a FOG episode. Objectives We aimed to evaluate the effects of DeFOG during a FOG‐provoking protocol: (1) after 4 weeks of DeFOG‐use in daily life against an active control group; (2) after immediate DeFOG‐use (within‐group) in different medication states. Method In this randomized controlled trial, 63 people with PD and daily FOG were allocated to the DeFOG or active control group. Both groups received feedback on their daily living step counts using the device, but the DeFOG group also received on‐demand cueing. Video‐rated FOG severity was compared pre‐ and post‐intervention through a FOG‐provoking protocol administered at home off and on ‐medication, but without using DeFOG. Within‐group effects were tested by comparing FOG during the protocol with and without DeFOG. Results DeFOG‐use during the 4 weeks was similar between groups, but we found no between‐group differences in FOG‐severity. However, the within‐group analysis showed that FOG was alleviated by DeFOG (effect size d = 0.57), regardless of medication state. Combining DeFOG and medication yielded an effect size of d = 0.67. Conclusions DeFOG reduced FOG considerably in a population of severe freezers both off and on medication. Nonetheless, 4 weeks of DeFOG‐use in daily life did not ameliorate FOG during the protocol unless DeFOG was worn. These findings suggest that on‐demand cueing is only effective when used, similar to other walking aids. © 2024 International Parkinson and Movement Disorder Society.