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ABSTRACT Background and Objective To compare the efficacy of EUS–guided celiac plexus neurolysis (CPN) and celiac plexus irradiation with iodine-125 ( 125 I) seeds with absolute ethanol for relieving pain in patients with advanced pancreatic cancer. Methods We retrospectively analyzed data of 81 patients with advanced pancreatic cancer who underwent EUS-CPN or EUS- 125 I implantation between January 2017 and December 2020. Postoperative pain was assessed using visual analog scale (VAS) scores; self-assessments of quality of life and the median survival time were compared between the 2 groups. Results EUS-CPN and 125 I implantation were performed in 43 and 38 patients, respectively. Postoperative VAS scores were significantly lower than the preoperative levels in both groups. One week after the operation, 26 patients (60.5%) in the EUS-CPN group achieved partial pain relief, whereas no patients in the EUS- 125 I seed group experienced pain relief. However, after 4 weeks postoperatively, VAS scores had decreased, and the rate of partial pain relief was higher for EUS- 125 I seeds than for EUS-CPN. Self-assessments of quality of life were similar in both groups during the first 1 month after the procedure. Conclusions Both EUS-CPN and EUS- 125 I seeds can safely and effectively relieve pain in patients with advanced pancreatic cancer. Although EUS- 125 I seeds take additional time to show effects, the extent and duration of pain relief are better compared with CPN, and interestingly, the median survival time was different.
Zhang et al. (Fri,) studied this question.
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