487 Is there a correlation between systemic inflammatory index and extent of peritoneal carcinomatosis in advanced stage ovarian cancer?

Introduction/Background The extent of peritoneal carcinomatosis represents the most frequently encountered reason for incomplete debulking in advanced stage ovarian cancer. Therefore, attention was focused on identifying a prognostic marker which might provide a better identification of these cases preoperatively. Systemic inflammatory index, defined as the platelets*neutrophils/lymphocytes seems to provide significant information regarding the extent of the disease. Methodology Between 2014–2020 57 patients diagnosed with peritoneal carcinomatosis from ovarian cancer were submitted to surgery in Ion Cantacuzino hospital. Patients were further classified in three groups according to the extent of peritoneal carcinomatosis (defined by the peritoneal carcinomatosis index – PCI): PCI15 - 12 cases. Results Preoperative values of SII ranged between 871674 and 7458168, with a mean value of 2424479. Meanwhile, we determined the intraoperative volume of ascites, a mean value of 2350 ml being obtained (range 300–8000ml). Cases in the first group reported a mean SII level of 761786, those in the second group reported a mean SII level of 1276485 while those in the third group reported a mean SII level of 68760393 (pConclusion Preoperative SII seems to have a prognostic value in order to identify cases in which maximal debulking surgery is not feasible; therefore, such cases should be rather submitted to neoadjuvant chemotherapy followed by interval debulking surgery than to per primam attempt of debulking. Disclosures None.