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This is a Quantitative Study study.

October 9, 2025

Abstract Thu010: Single nuclear sequencing analysis of transcriptome changes in right ventricular cardiomyocytes at different ages revealed the mechanism of heart regeneration

Key Points

The study reveals the mechanism of heart regeneration through transcriptome changes in cardiomyocytes over age.
Key findings show that a specific cell type promotes human heart muscle cell division, providing insights into heart health.
Using single nuclear sequencing, researchers mapped cell composition changes related to DCRV in children with heart function issues.
These genetic insights may help develop new approaches to treating heart diseases affecting children.

Abstract

DCRV is a crucial disease that affect children heart function，which caused by abnormal developmental processes.The effect of abnormal muscles on blood flow to the heart can be fatal. Little is known about the cellular changes in abnormal muscles during the development of disease. Here，We conducted a sn-seq of the abnormal muscles and mapping of changes in cell composition, which revealed a cell type that promotes division of human heart muscle cells and captured the key genes of the cells. Our result shown key genetic information found in a cell type that promotes the regeneration of human heart muscle cells.

Abstract Thu010: Single nuclear sequencing analysis of transcriptome changes in right ventricular cardiomyocytes at different ages revealed the mechanism of heart regeneration

Key Points

Abstract

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