Abstract No. 546 Comparing Long-Term Follow-Up and Survival Outcomes Among Patients Treated with Super Selective Yttrium-90 Embolization for Primary Hepatocellular Carcinoma

Treatment of hepatic tumors with Yittrium-90 (Y-90) radioembolization is a currently utilized therapy for this invasive and often fatal malignancy. Two recently published studies utilizing high-dose super selective Y-90 radioembolization for curative treatment have shown excellent results. However, information regarding the effectiveness of selective Y-90 treatment and long-term outcomes specific to the segment of treatment is not robust. This study aims to evaluate our institution's experience and the long-term mortality outcomes among patients with primary hepatocellular carcinoma (HCC) treated with super selective Y-90 by comparing treatment locations. A total of 524 patient Y-90 cases from 2012 to 2023 were reviewed, and 135 patients were treated with super selective Y-90 for primary HCC. 1-year and 5-year follow-up data and all-cause patient mortality data were recorded. Any patient who was not treated with super selective Y-90 (lobar treatments) for treatment of primary HCC was excluded. Of these patients, 75 received single lobe super selective Y-90 and their all-cause mortality rates were compared. 135 patients were included in the analysis. 71 patients followed up at 1 year, 10 at 5 years, and 32 died based on chart records. 75 patients underwent super selective single lobe only Y-90 and of those all-cause mortality was 24%. Table 546.1 represents mortality outcomes in relation to the liver segment treated. There was no statistically significant difference between groups with p=0.7. This data, although with limitations due to the number of patients, suggests there is no significant difference in patient mortality depending on the liver segment treated with super selective Y-90 in patients with primary HCC. Further studies with larger patient populations as well as further consideration for confounding factors should be conducted before conclusions can be made.