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The article is devoted to the development of a simple chromatographic method for the simultaneous determination of the well-known antiseptics – chlorhexidine and triclosan – in new generation of antiseptic liquids. The dependences of the retention times of chlorhexidine and triclosan on the acetonitrile concentration in the mobile phase (from 30 to 60%) and pH (in the range of 3–8 units) for sorbents Luna C18, Nucleosil CN, Diaspher C4 were studied. A perfect separation of chlorhexidine, p-chloraniline (the most toxic product of chlorhexidine decomposition), dibutylphthalate (as a component of cosmetic alcohol), triclosan and ionol (butylhydroxytoluene, BHT, E321 – antioxidant agent) during 20 minutes in the gradient elution mode on the column with a domestic sorbent Diaspher C4 has been demonstrated.
Пирогов et al. (Mon,) studied this question.