Breast cancer is the most common cancer in women and one of the leading causes of morbidity and mortality in women worldwide. In Indonesia there are approximately 65,000 new cases, in 2020. Expression of HER-2 and Ki-67 were used as markers to determine the prognosis and predict the response of a certain therapeutic modality in breast cancer. This study aims to determine the relationship between the expression of HER-2 and Ki-67 with the histopathological grade in breast cancer. This research was a cross-sectional analytical study using secondary data obtained from 50 samples of breast cancer at Abdoel Wahab Sjahranie Hospital Samarinda during 2019 using purposive sampling technique. The Chi Square test was used to assess all of the data. The relationship between the expression of HER-2 and Ki-67 with the histopathological grade resulted in p-values of 0.334 and 0.115, respectively. There was no significant relationship between the expression of HER-2 and Ki-67 with the histopathological grade of breast cancer in Abdoel Wahab Sjahranie Hospital, Samarinda, East Borneo Indonesia.
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