Abstract Purpose: To analyze regional, racial, and gender disparities in the mortality rate for malignant colon neoplasm (MCN) in Brazil, discussing possible factors that contribute to these inequalities, in order to contribute to the formulation of more effective and targeted public health policies. Methods: This is a cross-sectional descriptive epidemiological study based on data from the DATASUS platform. The selected variables were mortality rates due to MCN in Brazil, during the period from 2022 to 2024, color/race, sex, and region. Results: During the period analyzed, the mortality rate from MCN in Brazil was 7. 99%. In 2022, the mortality rate was 7. 89%, with the highest rates observed among indigenous people (30. 77%), followed by Asians (10. 76%), blacks (8. 99%), mixed-races (8. 47%), and whites (6. 93%). In 2023, the mortality rate among indigenous people decreased to 15. 38%, but remained the highest, followed by blacks (10. 80%), mixed-races (8. 96%), Asians (8. 40%) and whites (7. 36%). In 2024, indigenous people again had the highest rate (28. 57%), followed by blacks (9. 86%), mixed-races (9%), Asians (8. 86%) and whites (7. 13%). When comparing the sexes, the difference in mortality rate was less than 1% between men and women during the period analyzed. Regarding the region of the country, the North region consistently had the highest mortality rate during the period analyzed. This data can be underestimated due to the dependence on the correct recording of information. Even so, the results indicate that indigenous people had the highest mortality rates, while the North region stood out with the highest rates. High mortality due to MCN may reflect more severe cases of the disease, not diagnosed early, increasing the risk of death. These data raise serious concerns because, in addition to demonstrating high mortality, they suggest a reflection of discrimination and less access to information and health services related to factors of color/race and geographic location. Conclusion: The discrepancy in mortality rates due to MCN seems to be associated with the evolution of the disease in regions with limited access to adequate medical follow-up. As a result, patients often seek medical care in advanced stages of the disease, requiring immediate hospitalization and a higher probability of dying. Preventive interventions and advances in public policies are urgent to reduce the mortality rates associated with MCN in Brazil. Citation Format: Ana Lúcia Soares Rosson, Luiza Nodari Candanedo, Yasmin Marques Loureiro, Rafaela Coelho Pires, Gabriela Gerevini Dal Alba, Júlia Larsen Dorcinio, Jéssica Meazza Bohnenberger, Mariana Schlindwein Afonso. Malignant Colon Neoplasm in Brazil: An Analysis of the Mortality Rate abstract. In: Proceedings of the 13th Annual Symposium on Global Cancer Research; 2025 Sep 16. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2025;34 (12Suppl): Abstract nr 24.
Loureiro et al. (Mon,) studied this question.