Pre-targeted delivery of Tetrazinylated Albumin-Zinc (II) Porphyrin Complex for Tumor Photodynamic Therapy

Key Points

• To develop a ZnPPA@Tz-BSA complex as an effective photosensitizer for tumor photodynamic therapy.
• Utilized tetrazine-modified bovine serum albumin and Zinc porphyrin to create the complex ZnPPA@Tz-BSA.
• Evaluated the complex's solubility and reactivity in vitro.
• Assessed the effectiveness of the complex in generating reactive oxygen species.
• ZnPPA@Tz-BSA demonstrated enhanced water solubility compared to other photosensitizers.
• The complex showed improved generation of reactive oxygen species, which is crucial for photodynamic therapy efficacy.