Abstract Background In phase 3 interventional studies, DTG/3TC demonstrated durable efficacy as a switch option for people with HIV-1 with virologic suppression and no pre-existing resistance-associated mutations (RAMs) or prior virologic failures (VFs). Historical or baseline genotypes are not always available in clinical practice. In a pooled TANGO/SALSA post hoc analysis, high virologic suppression (VS) rates were maintained after switching to DTG/3TC regardless of availability of prior genotype. Previous studies suggest that switching to DTG + 3TC with known pre-existing M184V/I may not impact effectiveness. We evaluate real-world effectiveness and impact of RAMs in people with HIV-1 switching to DTG + 3TC with unknown prior genotype. Methods A systematic literature review (SLR) was conducted, searching databases and relevant congresses reporting effectiveness and safety outcomes for people switching to DTG + 3TC with unknown prior genotype (published 1/2013-11/2024). Meta-analysis feasibility was conducted and appropriate. Based on SLR data, single-arm meta-analyses will produce point estimates for proportions of individuals with VF across studies. Results Of 310 publications identified representing 61,334 people with HIV-1 using DTG + 3TC, 13 reported outcomes for 3402 unique individuals switching to DTG + 3TC with unknown prior genotype. Eleven studies (n=3380) reported effectiveness outcomes at 6 months to 96 weeks (∼24 months). High VS rates (96%-100%) were maintained after switch. Overall, 0.30% (10/3380) of individuals experienced VF or discontinued for virologic reasons. M184V was detected at VF in 0.06% (2/3380) of individuals, and 1 person had T97A, E138K, and N155H, which confers low-level resistance to DTG, at treatment discontinuation (0.03%; 1/3380; HIV-1 RNA 540 copies/mL). In 5 studies reporting safety and/or tolerability outcomes at 30 weeks to 36 months (n=356), 0.84% (3/356) of individuals discontinued DTG + 3TC due to adverse events unrelated to study drug. Meta-analysis point estimates are forthcoming. Conclusion Consistent with interventional studies, DTG + 3TC was effective and well tolerated, with rare emergence of M184V/I or integrase RAMs, among people with HIV-1 switching to DTG + 3TC with unknown prior genotype in clinical practice. Disclosures John Boulos, PharmD, GSK: Stocks/Bonds (Public Company)|ViiV Healthcare: Employee Jeremy Fraysse, MS, GSK: Stocks/Bonds (Public Company)|ViiV Healthcare: Stocks/Bonds (Private Company) Eva Fernvik, PhD, GSK: Stocks/Bonds (Public Company)|ViiV Healthcare: Stocks/Bonds (Private Company) Bryn Jones, MBChB, GSK: Stocks/Bonds (Public Company)|ViiV Healthcare: Employee Gustavo Verdier, BSc, BPharm, MBA, ViiV Healthcare: Employee Julie Priest, MSPH, GSK: Stocks/Bonds (Public Company)|ViiV Healthcare: Employee Emilio Letang, MD, MPH, PhD, GSK: Stocks/Bonds (Public Company)|ViiV Healthcare: Employee
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