Infants born to mothers with congenital heart disease had an increased risk for major neonatal morbidity and 1-year mortality, with an adjusted odds ratio of 1.27.
Case-Control (n=3,930)
No
Does maternal adult congenital heart disease increase the risk of adverse pregnancy and infant outcomes?
Infants of mothers with adult congenital heart disease face increased risks of adverse pregnancy and neonatal outcomes, which are partially mediated by maternal placental syndrome and prematurity, though a large direct effect of maternal ACHD remains.
Effect estimate: OR 1.27 (95% CI 0.77–2.07)
Absolute Event Rate: 0.7% vs 0.3%
p-value: p=null
Abstract Objective Infants of mothers with adult congenital heart disease (ACHD) are at increased risk for adverse pregnancy and neonatal outcomes. We aim to identify mediators in the relationship between ACHD and pregnancy and infant outcomes. Study design Case-control study using linked maternal and infant hospital records. Structural equation modeling was performed to assess for potential mediators of pregnancy and infant outcomes. Result We showed an increased risk of multiple adverse infant and pregnancy outcomes among infants born to mothers with ACHD. Maternal placental syndrome and congestive heart failure were mediators of prematurity. Prematurity and critical congenital heart disease in the infant were mediators of infant outcomes. However, the direct effect of ACHD on outcomes beyond that explained by these mediators remained significant. Conclusion While significant mediators of infant and pregnancy outcomes were identified, there was a large direct effect of maternal ACHD. Further studies should aim to identify more factors that explain these infants’ vulnerability.
Young et al. (Thu,) conducted a case-control in Congenital Heart Disease (CHD) in mothers (n=3,930). Maternal Congenital Heart Disease (ACHD) vs. Mothers without congenital heart disease (control group) was evaluated on 1-year mortality (OR 1.27, 95% CI 0.77–2.07, p=null). Infants born to mothers with congenital heart disease had an increased risk for major neonatal morbidity and 1-year mortality, with an adjusted odds ratio of 1.27.