One-pot synthesis of α-(OCH₂CF₃)-substituted pyridines using TFE as a dual solvent–reagent

Key Points

• The aim is to develop an efficient one-pot synthesis method for trifluoroethoxy-substituted pyridines.
• Utilization of TFE as both solvent and reagent
• One-pot reaction approach
• Characterization of synthesized pyridines
• Evaluation of reaction conditions
• Successful synthesis of various α-(OCH₂CF₃)-substituted pyridines
• Demonstrated broad applicability in material science
• Potential enhancement of pharmaceutical compounds