Electrochemical C-H Trifluoromethylation of 4-Phenylthiazol-2amines

Key Points

• The aim is to develop a new method for C–H trifluoromethylation of specific amine compounds using electrochemical techniques.
• Utilized a glassy carbon electrode for electrochemical reactions
• Implemented sodium trifluoromethanesulfinate as the trifluoromethylating agent
• Conducted reactions in an undivided cell setup
• Successfully achieved trifluoromethylation of 4-phenylthiazol-2-amines
• Demonstrated good functional group tolerance in the described methodology
• Reactions showed promising yields and operational simplicity