Adults with uncomplicated type 1 diabetes exhibited a 20% greater increase in mean arterial pressure during exercise compared to healthy adults, associated with elevated oxidative stress.
Does uncomplicated type 1 diabetes cause an exaggerated exercise pressor reflex, and is it associated with oxidative stress?
Adults with uncomplicated type 1 diabetes demonstrate an exaggerated exercise pressor reflex that correlates with elevated oxidative stress, providing mechanistic insight into abnormal blood pressure responses during exercise.
Absolute Event Rate: 0% vs 0%
Adults with type 1 diabetes (T1D) often exhibit exaggerated increases in blood pressure (BP) during exercise, but the mechanisms driving this abnormal response remain unclear. We investigated whether heightened activation of the exercise pressor reflex and oxidative stress contribute to this phenomenon. Fifteen adults with uncomplicated T1D (7 women; 27±10 years; HbA1c 7.1±1.5%) and 20 healthy adults (11 women; 26±9 years; HbA1c 5.1±0.3%) performed graded intensities of isometric handgrip, followed by post-exercise ischemia (PEI) to isolate the muscle metaboreflex and, a cold pressor test (CPT). Beat-to-beat mean arterial pressure (MAP) and heart rate were recorded continuously, and serum oxLDL, a marker of oxidative stress, was measured. Patients with T1D exhibited a greater pressor response during handgrip exercise (e.g., 40%MVC ΔMAP in T1D = 41±10 vs. healthy = 34±9 mmHg, p=0.047), and this augmented pressor response was evident as early as 30s of isometric handgrip. In contrast, MAP responses during PEI (T1D = 34±11 vs. healthy = 32±11 mmHg; p=0.774) and CPT were not different between the groups. Serum oxLDL concentration was significantly elevated in patients with T1D and positively correlated with the magnitude of exercise pressor response (e.g., 40%MVC HG; r=0.744, p=0.006). Altogether, these findings suggest that T1D patients have augmented increases in exercise pressor reflex, likely driven by heightened muscle mechanoreflex activity. Importantly, elevated oxidative stress is a potential underlying mechanism that at least, in part, contributes to the exaggerated exercise pressor response in patients with T1D.
Nyarko et al. (Tue,) reported a other. Adults with uncomplicated type 1 diabetes exhibited a 20% greater increase in mean arterial pressure during exercise compared to healthy adults, associated with elevated oxidative stress.