Exploring the effects of renal and cardiac functions on the pharmacokinetics of vancomycin in patients undergoing cardiac surgery: a population pharmacokinetic analysis | Synapse
January 23, 2026Open Access
Exploring the effects of renal and cardiac functions on the pharmacokinetics of vancomycin in patients undergoing cardiac surgery: a population pharmacokinetic analysis
Key Points
This research aims to analyze how renal and cardiac functions influence vancomycin pharmacokinetics in patients undergoing cardiac surgery.
Established a population pharmacokinetic model for vancomycin
Analyzed data from patients undergoing cardiac surgery
Considered both renal and cardiac function in the model
Renal function positively influences vancomycin clearance
Cardiac function also impacts vancomycin pharmacokinetics
Findings suggest need for individualized dosing in cardiac surgery patients
Abstract
A vancomycin population pharmacokinetic model was established for cardiac surgery patients. Both renal and cardiac functions have confirmed effects on vancomycin pharmacokinetics.