What question did this study set out to answer?

To develop a method for synthesizing pyrazol-5-ones through a photoinduced radical cyclization of specific derivatives.

January 23, 2026

Visible Light-Induced Cyclization of N -Arylmethacrylohydrazides and Hydroxamic Acid Derivatives toward δ-Amidoalkylated Pyrazol-5-ones via 1,5-Hydrogen Atom Transfer

YCYangjian ChengMinjiang University GYGuocheng YinChangzhou University JYJin-Tao YuChangzhou University

Key Points

To develop a method for synthesizing pyrazol-5-ones through a photoinduced radical cyclization of specific derivatives.
Utilized visible light to induce a radical cascade cyclization
Syntesized starting materials included n-arylmethacrylohydrazides and hydroxamic acids
Evaluated a broad range of substrates
Achieved good yields of pyrazol-5-ones
Demonstrated excellent compatibility with various functional groups
Applied successfully for late-stage modifications of natural products and drug molecules

Abstract

A photoinduced radical cascade cyclization of N-arylmethacrylohydrazides and hydroxamic acid derivatives for the synthesis of pyrazol-5-ones via 1,5-hydrogen atom transfer was developed. A series of pyrazol-5-ones was obtained in good yield with a broad substrate scope and excellent functional group compatibility. The procedure was also applied to the late-stage modification of natural products and drug molecules.

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