P0882Personality Traits and Fatigue in Inflammatory Bowel Disease

Abstract Background Fatigue affects nearly 50% of inflammatory bowel disease (IBD) patients in clinical remission1 and over 80% of those with active disease2. Its aetiology is multifactorial3 resulting in considerable personal and societal costs. The five-factor model of personality classifies personality traits into five categories: extraversion, agreeableness, conscientiousness, neuroticism, and openness to experience. Each trait exists on a spectrum. This model facilitates the understanding of personal dynamics; allowing psychologists to predict behaviour in different scenarios.4 The relationship between personality traits and fatigue has not been previously examined in IBD. Methods Patients were recruited from the IBD service at a tertiary referral centre. Participants completed a questionnaire including the multidimensional fatigue inventory (MFI) and the Big Five Inventory-10. Partial mayo score or Harvey Bradshaw index was used to assess disease activity. Statistical analysis was completed using SPSS. Results Eighty-nine patients completed the questionnaire. The relationship between fatigue and disease activity was statistically significant (p = 0.012). Participants with inactive disease had a mean MFI score of 52.3 (SD 17.3) compared to 60.4 (SD 13.0) for those with active disease. Age, gender and body mass index did not show a correlation with fatigue. Linear regression analysis identified disease activity and neuroticism as being significant risk factors for increasing fatigue, while extraversion was negatively associated with fatigue. Spearman’s test confirmed a positive correlation between fatigue and neuroticism (p 0.001; Table 1). Extraversion and conscientiousness demonstrated a negative correlation (p = 0.008 and p = 0.004 respectively). Agreeableness and openness to experience did not have a significant correlation with fatigue scores. Conclusion IBD Patients with neuroticism as a dominant personality trait demonstrated higher levels of fatigue; lower levels of fatigue were associated with extraversion and conscientiousness. This highlights the importance of personality traits in IBD patients reporting fatigue. References: 1. Villoria A, García, V, Dosal A, Moreno L, Montserrat A, Figuerola A, Horta D, Calvet X, Ramírez-Lázaro MJ. Fatigue in out-patients with inflammatory bowel disease: Prevalence and predictive factors. PloS one. 2017. 12(7), e0181435. 2. Minderhoud IM, Samsom M, Oldenburg B. Crohn’s disease, fatigue, and infliximab: is there a role for cytokines in the pathogenesis of fatigue? World J Gastroenterol. 2007 Apr 14;13(14):2089-93. 3. Nocerino A, Nguyen A, Agrawal M, Mone A, Lakhani K, Swaminath A. Fatigue in Inflammatory Bowel Diseases: Etiologies and Management. Adv Ther. 2020 Jan;37(1):97-112. 4. McCrae RR, John OP. An introduction to the five-factor model and its applications. J Pers. 1992 Jun;60(2):175-215. doi: 10.1111/j.1467-6494.1992.tb00970.x. PMID: 1635039. Conflict of interest: Fennessy, Anne: No conflict of interest Girod, Parker: No conflicts of interest. Harpur, Lisa: No conflict of interest Kumar, Lakshman: No conflict of interest Sheridan, Juliette: No conflict of interest Cullen, Garret: No conflict of interest Doherty, Glen: Research or Education Grants (last 36 months): Abbvie, Pfizer, Janssen, Takeda, Tillotts, Celltrion, Abbott, Dr Falk, Amgen Speaker/Meeting Honoraria (Last 36 months): Abbvie, Dr Falk, Galapagos/Alfa Sigma, GSK McHugh, Louise: No conflict of interest Mulcahy, Hugh: No conflict of interest