ABSTRACT Obesity, a global health crisis, is often accompanied by metabolic disorders such as dyslipidemia and insulin resistance. This study investigates the anti‐obesity effects of black soybean meal insoluble dietary fiber modified by ultra‐high pressure and its impact on gut microbiota and metabolites in high‐fat diet‐induced obese mice. UHP modification significantly enhanced the oil‐holding capacity of IDF (9.47 ± 0.47 g/g) with minimal impact on purity (0.54% reduction). Animal experiments revealed that high‐dose HPIDF and UP‐IDF significantly inhibited weight gain, improved lipid profiles (reduced serum TG, TC, and LDL‐C; increased HDL‐C), and mitigated hepatic lipid deposition and liver injury in HFD mice. UP‐IDF intervention restored gut microbiota diversity, increased the abundance of beneficial bacteria (e.g., Blautia, Lactobacillus), and elevated short‐chain fatty acid levels, particularly butyric acid. These findings demonstrate that UHP‐modified IDF exerts synergistic anti‐obesity effects by modulating gut microbiota and its metabolites, offering a promising dietary strategy for obesity intervention and high‐value utilization of black soybean meal.
Liu et al. (Thu,) studied this question.