What question did this study set out to answer?

This research aims to develop a method for selective C–H aminoalkylation of cubanes using TBADT-mediated HAT.

January 25, 2026Chemical Communications1 citations

Photochemical HAT-Mediated Site-Selective C(sp³)−H Aminoalkylation of Cubanes Catalyzed by TBADT

JWJiaqi WangNorthern Illinois University XYXiuran Yang MLMingyang Liu

Key Points

This research aims to develop a method for selective C–H aminoalkylation of cubanes using TBADT-mediated HAT.
Utilized TBADT as a photocatalyst for HAT (hydrogen atom transfer) reactions.
Achieved C–H aminoalkylation without pre-functionalization of cubanes.
Conducted reactions under mild conditions to evaluate efficiency.
Successfully synthesized valuable 3D cubane-aryl methylamine bioisosteres.
Demonstrated the effectiveness of the radical addition strategy in C–H functionalization.

Abstract

Direct photocatalytic slelective C–H aminoalkylation of cubanes is achieved via TBADT-mediated HAT. This radical addition strategy bypasses pre-functionalization, offering a streamlined route to valuable 3D cubane-aryl methylamine bioisosteres under mild...

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