Abstract Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) is emerging as a minimally invasive alternative for benign gastric outlet obstruction (GOO). This study evaluated its safety, efficacy, and long-term outcomes. This international, multicenter retrospective study included 72 patients who underwent EUS-GE for benign GOO across 13 centers. Clinical success was defined as ability to tolerate solid food based on the GOO scoring system. Secondary outcomes included technical success and adverse events (AEs). Technical success was achieved in 97% of cases. Ability to tolerate solid food improved significantly, from 4% pre-procedure to 90% at 60 days post-procedure (P < 0.00001). Mean time to oral intake was 20.1 hours. AEs were mild, occurring in 6% intra-procedurally and 10% post-procedurally. Mean follow-up duration was 426.3 days. EUS-GE demonstrates high technical and clinical success rates with a favorable safety profile for benign GOO, offering a promising alternative to traditional surgical approaches.
Rizvi et al. (Thu,) studied this question.