What question did this study set out to answer?

To highlight Adult-onset Still’s Disease as a significant cause of pyrexia of unknown origin.

January 25, 2026

Adult-onset still’s disease as a cause of pyrexia of unknown origin - A diagnostic dilemma

Key Points

To highlight Adult-onset Still’s Disease as a significant cause of pyrexia of unknown origin.
Reported a case of a 42-year-old woman with prolonged fever and inflammatory arthritis.
Conducted extensive evaluations to rule out infections, malignancies, and common autoimmune diseases.
Used hyperferritinemia levels and Yamaguchi criteria for diagnosis.
The diagnosis of AOSD was established after fulfilling the Yamaguchi criteria.
Patient showed significant improvement with immunosuppressive therapy.
Elevated serum ferritin was noted as a key diagnostic marker.

Abstract

Abstract Pyrexia of unknown origin (PUO) continues to pose diagnostic challenges despite advancements in medical technology. Adult-onset Still’s Disease (AOSD), a rare systemic inflammatory disorder, remains an important but often overlooked cause. We report the case of a 42-year-old woman presenting with prolonged fever, inflammatory arthritis, and rash. Extensive evaluation excluded infectious, malignant, and common autoimmune causes. Marked hyperferritinemia and fulfillment of the Yamaguchi criteria led to a diagnosis of AOSD. The patient responded well to immunosuppressive therapy. AOSD should be considered in patients with PUO after the exclusion of common causes. Elevated serum ferritin and the Yamaguchi criteria are the key diagnostic tools.

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Cite This Study

Sheikh et al. (Tue,) studied this question.

synapsesocial.com/papers/6975b28afeba4585c2d6e112 https://doi.org/https://doi.org/10.4103/ajr.ajr_13_25

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