The regulation of gene expression through operons is a core concept taught in the undergraduate microbiology classroom. However, it is one of the most difficult topics for students to understand, and teaching challenging subject matter using a traditional lecture methodology can overwhelm and frustrate students. Operon structure and function are not easily relatable for students; providing a real-world experience whereby students participate in hands-on operon activities is essential when teaching this material effectively. By modifying Bybee’s 5E learning cycle to fit the college classroom, students can engage by visualizing the phenomenon through picture observations. They then receive an explanation in a mini-lecture before exploring the concept by acting out the processes of inducible and repressible operons. Students then discuss the material with their peers to elaborate on and reinforce these ideas. Throughout the entire activity, the instructor provides immediate feedback to ensure accuracy of the information being learned. When surveyed, 78.9% of students found the experience to be a good use of classroom time. Teaching gene expression and regulation in this active learning manner fosters a more collaborative classroom student experience while also enhancing instructor communication and technique.
Slowan-Pomeroy et al. (Thu,) studied this question.