Recent Discovery on Metal‐Free Construction of S‐Aryl Phosphorothioate Diesters

Key Points

• The aim is to explore metal-free synthesis methods for S-aryl phosphorothioates and their implications in sustainable chemistry.
• Reviewed recent innovations in metal-free coupling reactions, oxidations, and radical-induced methods.
• Analyzed electrochemical processes and multicomponent reactions.
• Examined the atom economy and functional group tolerance of these methods.
• Metal-free phosphorothioate synthesis offers a sustainable alternative to traditional metal-catalyzed methods.
• High atom economy and broad functional group tolerance were observed in the reported methods.
• Mechanistic studies revealed metal-free phosphorothiolation as a powerful tool in organic synthesis.