miR-30a-5p acts as a crucial sex-specific regulator of heart failure, mainly HFpEF, operating through estrogen signaling to balance cardiac compliance and metabolic adaptation in mice.
Does miR-30a-5p knockout or overexpression alter susceptibility to HFD/L-NAME-induced HFpEF in male and female mice?
miR-30a-5p acts as a crucial sex-specific cardioprotective regulator in HFpEF, operating through estrogen-dependent mechanisms to maintain cardiac compliance and metabolic adaptation in females.
Absolute Event Rate: 0% vs 0%
These findings establish miR-30a-5p as a crucial sex-specific regulator of HF (mainly HFpEF), operating through estrogen signaling to balance cardiac compliance and metabolic adaptation.
Zhang et al. (Thu,) reported a other. miR-30a-5p acts as a crucial sex-specific regulator of heart failure, mainly HFpEF, operating through estrogen signaling to balance cardiac compliance and metabolic adaptation in mice.