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February 2, 2026Open Access

Human papillomavirus (HPV) - driven head and neck squamous cell carcinoma (HNSCC) in a multi-ethnic developing country

Key Points

To investigate the prevalence of HPV-driven head and neck squamous cell carcinoma (HNSCC) in a multi-ethnic population.
Analyzed tumors from patients in a multi-ethnic cohort.
Identified HPV status using RNAISH or dual testing with p16<sup>INK4a</sup> IHC and HPVDNA.
Focused on oropharyngeal tumors as primary sites for HPV-driven HNSCC.
HPV-driven HNSCC was most commonly found in oropharyngeal tumors.
HPV16 was the predominant genotype identified in the cohort.
Implementing RNAISH and p16 testing could enhance treatment stratification in resource-limited settings.

Abstract

In our cohort, HPV-driven HNSCC was primarily encountered in tumours originating from the oropharynx. HPV16 was the most frequently encountered genotype in our cohort. It is recommended that determination of HPV status be based on single testing with RNAISH or dual testing of p16INK4a IHC in conjunction with HPVDNA as an acceptable alternative in resource limited settings to improve patient stratification for treatment as well as clinical outcomes.

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