Abstract Neglected Tropical Diseases (NTDs) are a group of parasitic diseases that are a major global health issue, particularly in developing countries. Natural products continue to be an area of ac-tive research and may offer new and effective treatments for NTDs. In this sense, Amaryllidaceae species have been studied for their potential antiparasitic activity, such as trypanosomiasis, leish-maniasis and others. A review on Web of Science and Scopus database was carried out to examines those species of the family, which have hitherto been examined for antiparasitic activity at last seven years. In this study, a total of 22 experimental articles related to the theme were identified out of the 444 found in the search platform. Overall, the study listed more than 40 Amaryllidaceae alkaloids which displayed activities including antileishmanial, antiplasmodial, anti-Trichomonas, anti-Trypanosoma, and antiviral effects. A virtual screening study of the Amaryllidaceae alkaloid database was also conducted aiming to find promising molecules with active potential against NTD-causing parasites, Leishmania infantum , Leishmania amazonensis , Trypanosoma cruzi , and Schistosoma mansoni . This library of compounds was derived from a recent review that en-compassed 636 Amaryllidaceae alkaloids. After the in-silico study, it was possible to identify three alkaloids (zephycarinatine B, zephycarinatine H, and zephygrantine E) with multitarget active potential. These findings highlight the continued importance of these plant species as a source of compounds for studying NTD’s.
Feu et al. (Sat,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: