Abstract: Background and Objectives: Limited data are available regarding symptomatic intracerebral hemorrhage (sICH) after intravenous thrombolysis (IVT) in acute ischemic stroke (AIS) from India. We analyzed the incidence, predictors, and functional outcome following sICH in the South Indian population. Methods: We retrospectively analyzed all patients with AIS who were treated with IVT between January 2012 and December 2022. The potential predictors of sICH and functional outcome at 3 months were investigated using univariate and multivariate analysis. Results: Of the 348 patients (71.55% men), 24 (6.92%) developed sICH. The patients with sICH had more severe stroke (National Institute of Health Stroke Scale NIHSS on admission 15.16 ± 5.07 versus 11.14 ± 5.48, P = 0.006), high blood glucose (BG) on admission ( P = 0.001), high creatinine levels ( P = 15 (OR = 3.58; 95%CI 1.96–6.35; P = <0.001), high admission BG (OR = 2.60; 95%CI 1.50–4.48; P = 0.001), and large vessel occlusion (OR = 2.49; 95%CI 1.41–4.38; P = 0.002) independently predicted poor functional outcome. Conclusion: The presence of hyperglycemia at stroke onset and cardioembolic stroke etiology predicted sICH after IVT.
Surendran et al. (Thu,) studied this question.