Abstract Background Major vascular complications are less frequent with trans-radial artery (TRA) access compared to transfemoral artery access. However, a substantial proportion of patients experience incomplete hemostasis following TRA intervention. This study aimed to identify factors associated with incomplete hemostasis and evaluate the predictive value of pre- and post-procedural activated clotting time (ACT). Methods A total of 2,024 patients who underwent TRA intervention were included in a single-center registry. Initial ACT was measured after sheath insertion and final ACT was measured before sheath removal. Patients were categorized into complete and incomplete hemostasis groups based on achieving complete hemostasis within two hours of continuous compression. Results Incomplete hemostasis occurred in 233 patients (18%). Initial and final ACT values were significantly higher in the incomplete hemostasis group compared to the complete hemostasis group (initial ACT: 146 ± 37 s vs. 136 ± 32 s, p 0.001; final ACT: 259 ± 85 s vs. 243 ± 72 s, p = 0.015). Multivariate analysis revealed that prolonged initial ACT (OR, 2.41; 95% CI, 1.71–3.39; p 0.001) and final ACT (OR, 2.25; 95% CI, 1.52–3.30; p 0.001) were independently significant predictors. Conclusions Initial and final ACT measurements add predictive value to conventional risk factors for incomplete hemostasis in patients undergoing TRA intervention.
Ahn et al. (Sat,) studied this question.