What question did this study set out to answer?

To evaluate the therapeutic effects of 18β-GA-loaded silver nanoparticles on neuroinflammation and endoplasmic reticulum stress in diabetic rats.

February 8, 20260 citations

18β-Glycyrrhetinic acid-loaded silver nanoparticles mitigate neuroinflammation and endoplasmic reticulum stress in the brain tissue of diabetic rats.

SPSeçil Nazife ParlakAğrı İbrahim Çeçen University SYSeda YakutBurdur Mehmet Akif Ersoy Üniversitesi AKAdem KaraErzurum Technical University

Key Points

To evaluate the therapeutic effects of 18β-GA-loaded silver nanoparticles on neuroinflammation and endoplasmic reticulum stress in diabetic rats.
Administered 18β-GA-AgNPs to diabetic rat models.
Assessed neuroinflammation and endoplasmic reticulum stress in brain tissue.
Utilized ultrastructural analysis for detailed observation.
Significant reduction in neuroinflammation markers.
Decreased endoplasmic reticulum stress observed in treated rats.
Potential for 18β-GA-AgNPs as a therapeutic strategy for neurodegeneration.

Abstract

These findings suggest that 18β-GA-AgNPs may represent a promising therapeutic strategy against diabetes-associated neurodegeneration, although further long-term, ultrastructural, and sex-inclusive studies are warranted.

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