A comparison of F/TAF and F/TDF as HIV pre-exposure prophylaxis in a predominantly cisgender women population in East and South Africa: a randomised, factorial, non-inferiority trial.

Key Points

• This research aims to compare the efficacy of F/TAF and F/TDF as pre-exposure prophylaxis (PrEP) for HIV in women.
• Randomised factorial design
• Participant population primarily consists of cisgender women
• Comparison between F/TAF and F/TDF as PrEP
• Assessment of adherence levels
• Non-inferiority of F/TAF was not demonstrated due to low statistical power
• Low adherence impacted the outcomes
• F/TAF remains supported by evidence for efficacy in HIV prevention regardless of sex