Left bundle branch area pacing improved symptoms and hemodynamic parameters in a patient with Ser43Asn mutant hereditary transthyretin cardiac amyloidosis and 2:1 atrioventricular block.
Case Report (n=1)
Does left bundle branch area pacing improve symptoms and hemodynamics in a patient with hereditary TTR amyloidosis and AV block?
This is the first documented case demonstrating that left bundle branch area pacing can improve symptoms and hemodynamics in a patient with Ser43Asn mutant transthyretin cardiac amyloidosis and AV block.
ABSTRACT Hereditary transthyretin (TTR) cardiac amyloidosis is a rare infiltrative cardiomyopathy. Involvement of the cardiac conduction system may lead to atrioventricular block. Left bundle branch area pacing (LBBAP) represents an emerging pacing strategy. We report a case of hereditary TTR amyloidosis with 2:1 atrioventricular block (second‐degree), a wide QRS escape rhythm, and reduced ejection fraction, in which LBBAP improved symptoms and hemodynamic parameters. To our knowledge, this is the first documented case of Ser43Asn TTR amyloidosis managed with LBBAP.
Yao et al. (Sun,) conducted a case report in Hereditary transthyretin (TTR) cardiac amyloidosis with Ser43Asn mutation (n=1). Left bundle branch area pacing (LBBAP) was evaluated on Symptoms and hemodynamic parameters. Left bundle branch area pacing improved symptoms and hemodynamic parameters in a patient with Ser43Asn mutant hereditary transthyretin cardiac amyloidosis and 2:1 atrioventricular block.
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