Single‐atom nanozymes (SANz) have attracted considerable interest due to their remarkable catalytic characteristics, which are ascribed to individual metal atoms anchored to different supports. High atom utilization, adjustable activity, and exceptional stability are some of the advantages of nanozymes. This review article addresses the synthesis, structural characterization, and use of SANz in the framework of food safety and nutritional value analysis. Furthermore, it provides an in‐depth study of support materials and characterization methodologies, encompassing carbon‐based supports as well as other forms of supports. Additionally, the catalytic performance of SANz was explored, providing a comprehensive analysis of evaluation methodologies and mechanistic insights. Various factors that affect the performance of enzyme mimics are also explored. In food safety, SANz facilitate the quick identification and breakdown of impurities, residual pesticides, antibiotics, mycotoxins, heavy metal ions, nutritional components, and additives like preservatives, antioxidants, and colorants. SANz in portable sensing devices facilitate on‐site, real‐time monitoring of nutritional content, supporting personalized nutrition strategies. In addition to their versatility in food safety and nutrition evaluation, SANz has the potential to address challenges relating to global food security and public health. The review concludes by discussing challenges, future perspectives, and emerging trends in the field, offering insights into potential research directions and applications.
Haider et al. (Thu,) studied this question.