Reconstitutable oral dry syrups are vital pharmaceutical dosage forms designed for medications that exhibit instability in aqueous environments, most notably antibiotics such as amoxicillin, cephalexin and ciprofloxacin. These formulations consist of dry mixtures of finely divided insoluble particles, typically ranging from 0.5 to 5 in diameter, intended to be suspended in a vehicle at the time of dispensing. This review evaluates the development of sugar-free systems to accommodate pediatric, geriatric and diabetic populations while utilizing natural suspending agents like fenugreek seed mucilage (Trigonella foenum-graecum), acacia and xanthan gum. Natural agents are prioritized due to their biodegradability, non-toxicity and superior thixotropic properties compared to synthetic alternatives. The article details comprehensive preformulation, formulation and post-formulation methods. Key evaluation parameters, containing micromeritic flow properties (Angle of Repose, bulk/tapped density), sedimentation volume (F) and in-vitro dissolution kinetics, are discussed. Findings indicate that natural polymers grant excellent physical stability and dose regularity, ensuring a long shelf life of at least two years in dry form.
Christopher Vimalson D.*, Alagarraja M., Naveen V., Alagusudha D., Anuroopa S. J., Nivetha M., Nivetha S., Ragoof Rahman B., Mugesh R. (Tue,) studied this question.