What question did this study set out to answer?

The aim is to explore how 4-PSQ influences redox balance and improves symptoms in Alzheimer's disease.

February 19, 2026Redox Report2 citationsOpen Access

Redox modulation contributes to the antidepressant-like and neuroprotective effects of 7-chloro-4-(phenylselanyl)quinoline in an Alzheimer’s disease model

RORenata L. de OliveiraUniversidade Federal de Pelotas MPMikaela P. PinzThe University of Sydney GVGuilherme T. VossUniversidade Federal de Pelotas

Key Points

The aim is to explore how 4-PSQ influences redox balance and improves symptoms in Alzheimer's disease.
Administered 4-PSQ in an Alzheimer's disease model.
Assessed behavioral outcomes related to depression and cognition.
Evaluated biochemical changes associated with Aβ toxicity.
4-PSQ restored redox homeostasis.
4-PSQ reduced neuroinflammatory responses.
4-PSQ improved behavioral outcomes linked to depression.

Abstract

By restoring redox homeostasis and attenuating neuroinflammatory responses, 4-PSQ effectively counteracted behavioral and biochemical disruptions associated with Aβ toxicity. These findings support 4-PSQ as a promising selenium-based therapeutic candidate targeting redox-driven features of AD, including comorbid depression and cognitive decline.

اسأل الذكاء الاصطناعي

Bookmark

View Full Paper

Cite This Study

Oliveira et al. (Mon,) studied this question.

synapsesocial.com/papers/6996a77aecb39a600b3ed358 https://doi.org/https://doi.org/10.1080/13510002.2026.2626641

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

اسأل الذكاء الاصطناعي

Bookmark

View Full Paper