Associations of systemic inflammatory markers with cancer survival outcomes: a systematic umbrella review

Key Points

• The aim is to evaluate the reliability of systemic inflammatory markers as prognostic indicators for cancer survival outcomes.
• Conducted an umbrella review of existing studies on systemic inflammatory markers and cancer survival.
• Evaluated the prognostic value of systemic inflammatory index and systemic inflammatory response index in various cancers.
• Analyzed data for consistency and reliability of findings across different cancer types.
• Systemic inflammatory index (SII) and systemic inflammatory response index (SIRI) are found to be reliable prognostic markers.
• Both SII and SIRI significantly correlate with cancer survival outcomes across multiple types of cancer.
• The findings support their potential role in guiding clinical decision-making.