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February 22, 2026Pathology0 citations

Clinical and haematological correlation of FLT3-ITD mutation in acute promyelocytic leukaemia: a two-decade tertiary centre experience on Malaysia’s East Coast

RZRazan Hayati ZulkefleeUniversiti Sains Malaysia RHR A A Hassan III.B. IsmailSultan Zainal Abidin University

Key Points

To evaluate the clinicopathological features and prognostic impact of FLT3 mutation in acute promyelocytic leukaemia patients.
Conducted a two-decade observational study in a tertiary centre in Malaysia.
Analyzed clinical and haematological data of APML patients.
Investigated the association between FLT3-ITD mutation and prognosis.
Association of FLT3-ITD mutation with poorer prognostic outcomes in APML patients was observed.
Noted influence of genetic heterogeneity on treatment response and prognosis.
Identified coagulopathy as a significant clinical complication affecting patient management.

Abstract

Background: Acute promyelocytic leukaemia (APML), classified as the M3 subtype by the FAB group and the World Health Organization in 2022, is known for its favourable prognosis when treated promptly despite life-threatening coagulopathy. Despite generally favourable outcomes with targeted therapy, genetic heterogeneity such as FLT3 mutation may influence prognosis. This study aimed to evaluate the clinicopathological features and prognostic impact of FLT3 mutation in APML patients on the East Coast of Malaysia.

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