What question did this study set out to answer?

To compare the Friedewald and Sampson equations in terms of LDL-cholesterol calculation and invalid results.

February 22, 2026

Comparison of Friedewald and Sampson equations for calculation of LDL-cholesterol

Key Points

To compare the Friedewald and Sampson equations in terms of LDL-cholesterol calculation and invalid results.
Evaluated the effectiveness of Friedewald and Sampson equations in clinical settings.
Assessed the percentage of invalid results linked to each equation.
Analyzed agreement between the two equations when triglycerides were ≤4.5 mmol/L.
Identified significant differences in invalid results between the two equations.
Demonstrated good agreement in LDL-cholesterol results when triglycerides were ≤4.5 mmol/L.

Abstract

Background: Both the Friedewald and Sampson-NIH equations can be used for LDL-cholesterol (LDL-C) calculation, but they differ in permissible maximum triglyceride concentrations (Friedewald: 4.5, Sampson-NIH: 9.0 mmol/L). This study examined the percentage of invalid results in clinical practice associated with use of these equations and the agreement between the two equations when triglycerides were ≤4.5 mmol/L.

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Cite This Study

Lee et al. (Sun,) studied this question.

synapsesocial.com/papers/699a534bfdaf4e3c1268ef16 https://doi.org/https://doi.org/10.1016/j.pathol.2026.01.180

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