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February 22, 2026

Estimation of macrophage migration inhibitory factor in gingival crevicular fluid of obese and non-obese patients with periodontitis using ELISA: a case-control study.

Key Points

This research aims to investigate the levels of macrophage migration inhibitory factor in gingival crevicular fluid of obese versus non-obese patients with periodontitis.
Conducted a case-control design comparing obese and non-obese patients
Utilized ELISA to measure macrophage migration inhibitory factor levels in gingival crevicular fluid
Assessed inflammation resolution and clinical healing in periodontitis
Obese patients show sustained elevation of MIF in gingival crevicular fluid despite plaque control
Findings indicate a state of 'metabolic inflammatory priming' in obesity
Implying a need for personalized periodontal management strategies for obese individuals.

Abstract

Obesity acts as a biological modifier that limits the resolution of inflammation and clinical healing in periodontitis. The sustained elevation of GCF MIF in obese patients, despite effective plaque control, suggests a state of "metabolic inflammatory priming." These findings highlight the need for risk-stratified, personalized periodontal management for patients with obesity.

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Cite This Study

Palwankar et al. (Fri,) studied this question.

synapsesocial.com/papers/699a9dc0482488d673cd3d41 https://doi.org/https://doi.org/10.3290/j.qi.b6912851

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