What does this research mean for the field?

In patients aged 80 years and older, the use of β-blockers or calcium channel blockers (CCBs) is associated with syncope and loss of consciousness, while CCBs are additionally associated with falls and edema. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The central aim is to investigate adverse events associated with antihypertensive medications in patients aged 80 years and older.

February 25, 2026

Antihypertensive drug-induced adverse events in patients aged 80 years and older: A retrospective analysis using the Japanese Adverse Drug Event Report Database

Key Result

In patients aged ≥80, β-blockers or CCBs were associated with syncope/loss of consciousness, and CCBs with falls and edema according to JADER data.

Key Points

The central aim is to investigate adverse events associated with antihypertensive medications in patients aged 80 years and older.
Utilized the Japanese Adverse Drug Event Report Database (JADER) for analysis.
Focused on a cohort of patients aged ≥ 80 years.
Analyzed specific adverse events linked to beta-blockers and calcium channel blockers.
Identified syncope and loss of consciousness related to beta-blockers and calcium channel blockers.
Found that falls and edema were notably associated with calcium channel blockers.

Structured PICO

What specific adverse events are associated with antihypertensive drug use in patients aged 80 years and older?

Population

Patients aged 80 years and older from the Japanese Adverse Drug Event Report (JADER) Database

Intervention

Antihypertensive drugs (specifically β-blockers and calcium channel blockers)

Outcome

Specific adverse events associated with drug usesafety

In patients aged 80 years and older, the use of β-blockers and CCBs is associated with significant adverse events including syncope, falls, and edema, highlighting the need for careful monitoring in this demographic.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

This study, which employed the JADER database, identified specific AEs associated with drug use in patients aged ≥ 80 years. These AEs included syncope/loss of consciousness associated with β-blockers or CCBs as well as falls and edema associated with CCBs.

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Cite This Study

Matsushima et al. (Sun,) reported a other. In patients aged ≥80, β-blockers or CCBs were associated with syncope/loss of consciousness, and CCBs with falls and edema according to JADER data.

synapsesocial.com/papers/699e90eff5123be5ed04e2d0 https://doi.org/https://doi.org/10.5414/cp204943

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