YBX1 Modulated Corneal Neovascularization Induced by Alkali Burn via m 5 C-Dependent Regulation of the STAT3/HIF-1α/VEGFA Axis

Key Points

• This research aims to explore how YBX1 influences corneal neovascularization (CoNV) through m5C modification of specific mRNAs.
• Investigated the role of YBX1 in CoNV using an alkali burn model.
• Analyzed the stability of m5C-modified mRNAs for STAT3 and VEGFA.
• Evaluated the effects of YBX1 inhibition with SII on the JAK1/STAT3/HIF-1α pathway.
• Inhibition of YBX1 decreased corneal neovascularization.
• Reduced stability of m5C-modified mRNAs for STAT3 and VEGFA was observed.
• The JAK1/STAT3/HIF-1α axis was effectively counteracted by the YBX1 inhibitor.