What question did this study set out to answer?

This research aims to evaluate the combined diagnostic efficacy of multiple biomarkers for rheumatoid arthritis.

February 25, 2026

Combined diagnostic value of rheumatoid arthritis-specific citrullinated protein, haemoglobin-to-red cell distribution width ratio, and anti-CCP antibody in rheumatoid arthritis.

Key Points

This research aims to evaluate the combined diagnostic efficacy of multiple biomarkers for rheumatoid arthritis.
Identified predictive values of rheumatoid arthritis-specific citrullinated proteins (RA-CP) and haemoglobin-to-red cell distribution width ratio (HRR)
Analyzed the role of anti-CCP antibody in RA diagnosis
Explored the potential clinical role of MPV/PC in rheumatoid arthritis
RA-CP identified as a risk factor for rheumatoid arthritis
HRR recognized as a protective factor for rheumatoid arthritis
Combined detection of RA-CP, HRR, and anti-CCP antibody enhanced diagnostic sensitivity and accuracy

Abstract

RA-CP and HRR were identified as independent predictors of RA, including RA-CP as a risk factor for RA and HRR as a protective factor for RA. Combined detection of RA-CP, HRR, and anti-CCP antibody could enhance the accuracy and sensitivity of laboratory diagnosis. Although MPV/PC did not demonstrate significant independent predictive value in this study, this represents the first exploration of its potential clinical role in RA.

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Combined diagnostic value of rheumatoid arthritis-specific citrullinated protein, haemoglobin-to-red cell distribution width ratio, and anti-CCP antibody in rheumatoid arthritis.

Key Points

Abstract

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