Is three really what we need? Relative effectiveness of benzathine penicillin G and doxycycline treatment regimens for late or unknown duration syphilis in 6 United States jurisdictions, 2016–2021

Key Points

• To determine if there is a difference in treatment effectiveness between varying doses of benzathine penicillin G and doxycycline for late or unknown duration syphilis.
• Compared 1 and 3 doses of benzathine penicillin G (BPG) in treatment regimens
• Analyzed treatment effectiveness in six U.S. jurisdictions from 2016 to 2021
• Compared BPG with doxycycline for late or unknown duration syphilis
• No difference found in effectiveness between 1 and 3 doses of benzathine penicillin G
• No significant difference between 3 doses of BPG and doxycycline
• Findings suggest similar treatment outcomes regardless of dosing regimen