Biological aging and immunosenescence are central to longevity, yet their interplay in centenarians remains unclear. We conducted a cross-sectional study in 160 Colombian centenarians to examine associations between biological age (PhenoAge), immunosenescence and age-related clinical variables. Cytokine profiling (n = 114) and lymphocyte immunophenotyping (n = 42) were assessed. It was observed that better QoL and well-being were significantly associated with lower biological age, while depressive symptoms, prior tobacco use, elevated levels of RANTES and G-CSF as well as a distinct CD8+ T cell phenotype including greater CD27− CD28+ central memory, effector memory, and KLRG1− CD57+ terminally differentiated effector memory T cells (TEMRA), and fewer KLRG1+ CD57+ TEMRA cells were linked to higher biological age. Centenarians were classified into three categories: vigorous (10%), resilient (46.25%), and vulnerable (43.75%). Cytokine levels were similar across the groups. These findings challenge the notion of immunosenescence in centenarians and highlight the value of translational research in geroscience.
Anaya et al. (Mon,) studied this question.