Clinical and Inflammatory Predictors of False-Negative Ultrasound in Children With Suspected Appendicitis: A Prospective Cohort Study. | Synapse
February 26, 2026
Clinical and Inflammatory Predictors of False-Negative Ultrasound in Children With Suspected Appendicitis: A Prospective Cohort Study.
Key Points
This research aims to identify clinical and inflammatory factors that lead to false-negative ultrasound results in children suspected of having appendicitis.
Prospective cohort design
Assessment of children with suspected appendicitis using ultrasound
Evaluation of clinical and inflammatory markers like Alvarado scores and CRP levels
Analysis of associations with false-negative ultrasound findings
False-negative ultrasound results occurred in 8.9% of cases.
Higher Alvarado scores correlated with increased likelihood of missed appendicitis.
Prolonged symptoms were linked to false-negative imaging.
Elevated CRP levels were independently associated with missed diagnoses.
Abstract
False-negative US occurred in 8.9% of children with suspected AA. Higher Alvarado scores, prolonged symptoms, and elevated CRP were independently associated with missed AA despite negative imaging.